The consortium of the RISK-IR project brings together expertise from 13 research groups of 10 institutions from 7 European countries.
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The School of Medicine is the heart of Second University of Naples. Many laboratories devoted to biomedical research are localized close to the sites devoted to different clinical activities on patients.
Consequently, a number of collaborations have been established so far among distinct clinical disciplines, and above all, between clinicians and biomedical researchers, enabling to focus research activity on topics that are of pressing clinical relevance.
Prof Umberto Galderisi has the expertise, leadership and motivation necessary to successfully carry out the proposed work. I have a broad background in molecular and cell biology, with specific training and expertise in key research areas for this application.
As post-doc at Second University of Naples and at Museum Nationalle Histoire Naturelle of Paris (France) I carried out studies on genes involved in regulation of cell proliferation, differentiation and apoptosis of normal and tumor neural cells. To carry out these studies, I learnt about antisense oligonucleotides and how to silence gene expression. As visiting researcher at Jefferson Medical College of Philadelphia (PA) and as adjunct assistant professor at Temple University of Philadelphia (PA), I expanded my research to include studies on stem cell biology with a particular emphasis on cell cycle regulation. Research experiences at Tulane University, New Orleans (LA) and at University of Hamburg (Germany) shifted my interest on mechanisms that regulate stem cell senescence. This is currently my first research interest, since there is evidence that the complex process of ageing is at least partially related to senescence of stem cells thereby blocking their function to replenish tissue and to repair damaged tissue areas.
Also my experience as PI or co-Investigator on several previous Italian-funded grants creates the groundwork for the proposed research. In addition, I successfully administered these grants and collaborated with other researchers in Italy, Europe and USA. I published several peer-reviewed publications from each project I carried out. Specifically, in the last four years I have a good track of publications on issues related to senescence of stem cells.
My previous research experience allowed me understanding the importance of frequent communication among project members and of constructing a realistic research plan, timeline, and budget. The current application is based on my previous work, and I have chosen co-investigators who provide additional expertise for a successful execution of the proposed project. In summary, my expertise and experience have prepared me to lead the proposed project.