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The consortium of the RISK-IR project brings together expertise from 13 research groups of 10 institutions from 7 European countries.


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University of Sussex (UoS), UK.

logo UoSThe Genome Damage and Stability Centre (GDSC) is internationally recognised as a world-leading research Centre dedicated to understanding the basic science of DNA damage and genome stability.

The GDSC is located within the University of Sussex (UoS) and has close links with the University of Sussex Life Sciences Division. Recently, the Brighton and Sussex Medical School (BSMS) was established at the UOS, enhancing the interface between basic and clinical research.

The GDSC encompasses eighteen research groups, which are entirely focused on understanding mechanisms responding to DNA damage and enhancing genomic stability. There is a high quality tissue culture suite with specialised facilities for analysis of patient derived cell lines. The GDSC interfaces with UK hospitals to facilitate diagnosis of human DNA damage response disorders. The GDSC has state of the art microscopy facilities. There is a mouse facility within Life Sciences Division of the UOS that is used by GDSC members.

Dr. Penny Jeggo has worked in the field of DNA damage responses and radiation biology for more than twenty years. She has particularly focused on mechanisms of DNA double strand break repair and its interface with damage response signalling using cellular, molecular and biochemical approaches. She is particularly interested in the role of double strand break repair during development and the impact of unrepaired double strand breaks. She interfaces with UK and international clinicians to carry out diagnosis of radiosensitive, immunodeficiency patients and has made major contributions to the identification of the underlying genetic defects causing radiosensitivity. In recent work, she has established a mouse model for LIG4 syndrome, a disorder conferring clinical radiosensitivity. In addition to her basic research work, she has contributed to the issue of radiation protection both through the analysis of responses to low dose irradiation and through contributions to committees. She is a member of UK’s Committee on Medical Aspects of Radiation in the Environment (COMARE) and has been a member of several work groups examining the impacts of radiation. She is a committee member of UK’s Association for Radiation Research and has contributed to lectures on MSc radiation biology courses. She was a member of the EU RISC RAD programme.


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