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Events

The RISK-IR team takes every opportunity to disseminate the project and its results. For this reason it is also foreseen that the RISK-IR consortium will participate in a variety of events.

Please see below a list of events we have attended with links to relevant documents.

April 2015, RISK-IR Integration meeting (Paris)

As noted in the report from the first periodic meeting, the RISK-IR consortium held a meeting in April 2015 to consider in depth the further integration of results of partner labs, and relating RISK-IR findings to risk extrapolation frameworks for low dose radiation risk. Two invited experts attended and contributed: Dr David Brenner of Columbia University Medical Centre and Dr Ohtsura Niwa of Fukushima Medical University. Material was also supplied by Dr Julian Preston, formally of the US Environmental Protection Agency.

The invited presentations covered a wide range of topics including:

 

  • The current risk project models used in radiation protection
  • The rationale for use of the linear non-threshold (LNT) model
  • Challenges to the LNT model
  • How genetic variation in susceptibility is an important consideration in risk protection and radiation protection
  • The potential importance of the stem cells niche as well as stem cells themselves as targets in radiation carcinogenesis
  • Competition for niche occupancy as a selective process that may impact on cancer risk following exposure
  • The potential different processes that may impact on dose-rate effects compared to low dose effects
  • The value of integrating basic biological knowledge and epidemiological evidence to improve risk projection
  • The use of the ‘adverse outcome pathway’ concept for integration of biology and epidemiology.

Partner presentations followed in standard work package order and it was clear that significant progress had been made in all areas since the first periodic meeting. Most discussion centred around placing individual partner lab findings in context. This discussion led to discussions to re-consider the format and sequence of presentations for the second periodic meeting and the structure of the second highlights report to integrate by:

  • Organisational level
  • Issue of interest.

Relating findings to proposed adverse outcome pathways for radiation carcinogenesis, the Hanahan & Weinberg ‘hallmarks of cancer’ or similar frameworks for radiation carcinogenesis will be important for the future dissemination of RISK-IR findings to a wider scientific audience through reviews and presentations.

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